Company

Aviceda Therapeutics is a private, clinical-stage biotechnology company based in Cambridge, Massachusetts. The company specializes in developing next-generation immunomodulators to address various diseases, with a particular focus on those involving the innate immune system and chronic, non-resolving inflammation. ### Key Focus Areas - **Glyco-Immune Therapeutics**: Aviceda s proprietary Glyco-Code technology platform and High Affinity Ligands of Siglecs (HALOS™) nanotechnology are leveraged to modulate the innate immune response. This innovative approach targets glyco-immune checkpoints and exploits interactions between glycans and innate immune cells. ### Therapeutic Pipeline 1. **Ophthalmology**: - AVD-104: An intravitreal glycomimetic nanoparticle for geographic atrophy (GA) secondary to age-related macular degeneration. Currently in Phase 2b/3 clinical trials. - AVD-302: In development for diabetic retinopathy. - AVD-401: Targeting retinoblastoma. 2. **Other Indications**: - AVD-601: Oncology - AVD-701: Neurology - AVD-801 and AVD-901: Fibrosis ### Technology and Platforms 1. **Cell-Based High-Throughput Screening (HTS)**: Enables rapid screening, selection, and optimization of ligands with high affinity and specificity for innate immune cells. 2. **Nanoparticle Technology**: Proprietary delivery system for therapeutics, exemplified by the glycan-coated nanoparticles in AVD-104. ### Funding and Development Aviceda recently secured $207.5 million in Series C financing to advance its lead program, AVD-104, into pivotal trials. This substantial funding was backed by prominent healthcare funds and investors, demonstrating strong confidence in the company s potential. ### Leadership and Expertise The company boasts a cross-disciplinary team of recognized scientists, clinicians, and drug developers. Following the Series C financing round, Aviceda expanded its board of directors with industry experts, further strengthening its leadership position. In conclusion, Aviceda Therapeutics is well-positioned to address a wide range of inflammatory, degenerative, and fibrotic diseases through its innovative glyco-immune therapeutics and advanced technology platforms. The company s robust pipeline, cutting-edge technology, and strong financial backing make it a notable player in the biotechnology industry.

Citigroup Inc., commonly known as Citi, is a multinational investment bank and financial services company headquartered in New York City. With a rich history dating back to 1812, Citi has evolved into one of the world's leading financial institutions. ## History and Formation Founded as the City Bank of New York in 1812, Citi has grown through numerous mergers and innovations. A significant milestone was the 1998 merger of Citicorp and Travelers Group, forming Citigroup. However, Travelers was spun off in 2002. ## Structure and Operations Citi operates through two major divisions: 1. Institutional Clients Group (ICG): Offers investment banking, corporate banking, treasury and trade solutions, and securities services. 2. Personal Banking and Wealth Management (PBWM): Includes retail banking, credit card services, and wealth management. The company provides a wide range of financial services, including: - Retail, commercial, and investment banking - Securities brokerage - Trade and securities services - Wealth management solutions - Accounts and deposit services - Loans and mortgages - Small business banking solutions - Corporate and institutional services ## Global Presence Citi maintains a significant global footprint, serving clients in the Americas, Europe, the Middle East, Africa, and the Asia-Pacific region. Its diverse client base includes individuals, corporations, small businesses, and institutional and government entities. ## Key Initiatives and Innovations - Pioneered the world's first ATM and introduced 24-hour PC banking in the UK - Implemented Smart Banking branches and 24-hour service units globally - Launched innovative credit card products and expanded retail banking operations - Committed to diversity and inclusion (D&I) and environmental, social, and governance (ESG) initiatives ## Leadership Jane Fraser became CEO in February 2021, making history as the first woman to lead a major Wall Street firm. Under her leadership, Citi has intensified its focus on addressing social issues, including the U.S. racial wealth gap through its Action for Racial Equity initiative. ## Financial Status As one of the Big Four banking institutions in the United States, Citi is considered a systemically important bank by the Financial Stability Board. It consistently ranks among the top global investment banks and maintains a strong position in various financial rankings: - #24 in the Forbes Global 2000 (2023) - 36th on the Fortune 500 (2023) Citi's continued evolution and adaptation to the changing financial landscape solidify its position as a key player in the global banking industry.

World Liberty Financial (WLFI) is a decentralized finance (DeFi) platform associated with the Trump family. This comprehensive overview highlights key aspects of the project: Core Functionality: WLFI provides DeFi services including borrowing, lending, and investing in cryptocurrencies. It aims to offer an alternative to traditional banking, promoting financial accessibility. Token Structure: The native $WLFI token is central to operations, with 20% allocated to the founding team, 17% for user rewards, and 63% available for public purchase. Partnerships: WLFI has adopted Chainlink standard for on-chain data and cross-chain connectivity, enhancing security and interoperability. Portfolio: The company's wallet holds diverse cryptocurrencies, including $USDC, $ETH, $AAVE, $WBTC, and $LINK. Recent Activities: WLFI exchanged nearly $10 million worth of $WBTC for $ETH and converted some to $USDT, transferring $38.4 million to Coinbase. Governance: The platform features a community-driven model through the $WLFI token, allowing holders to vote on key development proposals. Regulatory Approach: WLFI plans to use a Regulation D token offering, which allows fundraising without full securities registration, raising concerns about transparency and investor protection. Market Impact: While aiming to democratize DeFi access, critics view it as an attempt to profit from Donald Trump's brand. Success depends on building trust and transparency. Upcoming Projects: WLFI is linked to other projects like Flockerz, a DAO set to launch soon, which has generated significant interest and funding.

Swave Photonics, founded in 2022 and based in Leuven, Belgium, and Silicon Valley, California, is a pioneering company in holographic display technology. Spun out from imec, a renowned Belgian research organization, Swave focuses on augmented and virtual reality (AR/VR) and spatial computing. The company's flagship innovation is the world's first dynamic holographic display chip, known as the Holographic eXtended Reality (HXR) technology. This groundbreaking technology utilizes standard CMOS semiconductor processes and non-volatile Phase Change Material (PCM) to create ultra-high-resolution 3D images. Key features of the HXR technology include: - High-Resolution Images: Produces 3D images with a pixel pitch of less than 300nm, enabling vivid and realistic holograms up to 64 gigapixels. - Compact Form Factors: Designed for everyday use in devices such as smart glasses, compatible with prescription lenses. - AI-Powered Spatial Computing: Integrated with AI services like image recognition, visual search, navigation, and translation. - Cost-Effective and Scalable: Utilizes CMOS technology and semiconductor economics for affordability and scalability. The primary application of Swave's HXR technology is in low-cost, lightweight AR smart glasses with all-day battery life. However, its potential extends to heads-up automotive displays and other immersive holographic experiences without the need for glasses or goggles. Swave Photonics has garnered significant recognition, including the CES 2025 Innovation Award for its HXR platform, the SPIE Startup Challenge, and being a Luminate Investment finalist. The company has also secured several non-dilutive investments and grants. Led by CEO Mike Noonen, Swave boasts a strong management team with extensive experience in semiconductors, photonics, IC design, and computer-generated holography. This expertise positions Swave Photonics at the forefront of revolutionizing the AR/VR and spatial computing industries with its innovative holographic display technology.

NuScale Power is a pioneering company in small modular reactor (SMR) technology, offering innovative and scalable nuclear power solutions. Their flagship product, the NuScale Power Module (NPM), represents a significant advancement in nuclear energy. ### NuScale Power Module (NPM) - The NPM is a 250 megawatts thermal (MWt) integral pressurized water reactor (PWR). - Each module measures 76 feet tall and 15 feet in diameter, generating 77 megawatts electric (MWe) of electricity. - It utilizes gravity-driven natural circulation for primary coolant in both normal operation and shutdown modes. ### Design and Safety Features - The NPM integrates the reactor core, steam generators, pressurizer, and containment within a single pressure vessel. - Modules are submerged in a below-grade pool of water within a Seismic Category 1, aircraft impact-resistant building. - Passive safety systems can cool and depressurize the containment vessel even during a loss of external power. ### Scalability and Flexibility - NuScale's VOYGR power plant design can accommodate up to 12 NPMs, with a total gross output of 924 MWe. - Smaller configurations include VOYGR-4 (308 MWe) and VOYGR-6 (462 MWe) plants. - The design allows for incremental plant capacity growth with minimal operational disruption. ### Operational and Maintenance Aspects - Fuel: Less than 4.95% enriched UO2 with a 24-month fuel cycle. - Underwater refueling allows continuous operation of other plant modules. - 60-year design life with a high capacity factor of 92-95%. ### Global Interest and Partnerships - NuScale is collaborating with over a dozen governments and organizations worldwide. - Significant interest in VOYGR plants across the United Kingdom, Europe, the Middle East, Africa, and Asia. ### Regulatory and Technological Maturity - The design leverages 50 years of light-water-cooled PWR technology. - Many systems and components are at a high technology readiness level (TRL). NuScale Power's SMR technology aims to provide a smarter, cleaner, safer, and cost-competitive solution for diverse electrical and process heat applications, positioning the company at the forefront of next-generation nuclear energy.

Nextracker Inc. is a leading energy solutions company specializing in solar tracker and software solutions for utility-scale and distributed generation solar projects globally. Founded in 2013 and headquartered in Fremont, California, USA, Nextracker has established itself as a pioneer in the solar energy industry. The company offers innovative products and solutions, including: - NX Horizon and NX Horizon-XTR: Advanced solar tracking solutions designed for various terrains - TrueCapture: A self-adjusting tracker control system that optimizes individual tracker row positions - NX Navigator: Software for monitoring, controlling, and protecting solar projects Nextracker's intelligent, integrated solar tracker and software solutions are designed to optimize plant performance and maximize energy production. The company's systems follow the sun from dawn until dusk, enhancing efficiency and reducing capital expenses. Since 2015, Nextracker has maintained its position as the global leader in solar trackers, with over 100 gigawatts of trackers shipped worldwide to more than 800 projects across 30+ countries. The company holds more than 175 patents and has nearly 200 pending, demonstrating its commitment to innovation. Key financial and operational details include: - IPO: February 9, 2023, with an initial price of $24.00 per share - Revenue: $1.5 billion (FY22) - Employees: Approximately 1,050 - Former parent company: Flex Ltd. Nextracker is led by a highly experienced executive team, including co-founder and CEO Daniel S. Shugar. The company has a global presence, partnering with top developers, contractors, and asset owners in the renewable energy industry. Leveraging a robust global supply chain network, Nextracker has facilities in every major region. Committed to sustainability, Nextracker focuses on Environmental, Social, and Governance (ESG) practices. The company aims to enable responsible and sustainable renewable energy and is a founding member of Renewables Forward.

Lightchain AI is a cutting-edge platform that seamlessly integrates artificial intelligence (AI) with blockchain technology. This innovative approach aims to revolutionize the development and operation of decentralized applications (dApps). The platform's key features include: ### Core Components 1. **Proof of Intelligence (PoI)**: A novel consensus mechanism that rewards nodes for performing valuable AI computations, addressing issues such as bias, scalability, and transparency in the blockchain space. 2. **Artificial Intelligence Virtual Machine (AIVM)**: A specialized environment optimized for AI-specific tasks, supporting popular frameworks like TensorFlow and PyTorch while ensuring data security through advanced cryptographic techniques. ### Technical Architecture Lightchain AI employs a modular, layered architecture that combines blockchain, AI computation engines, and data storage systems. It utilizes decentralized nodes for validation, computation, and storage, incorporating sharding and Layer 2 solutions to maintain high performance. ### Tokenomics The native Lightchain Token (LCAI) serves multiple purposes within the ecosystem, including payments for AI tasks, governance participation, and access to premium AIVM features. The token distribution is designed to prevent centralization, with a deflationary mechanism built into the system. ### Roadmap The project's development is structured into five phases, from prototype development to global adoption, with a focus on expanding ecosystem growth and industry integration. ### Governance and Security Lightchain AI emphasizes decentralized governance and employs advanced cryptographic techniques to ensure data privacy and security. ### Market Potential The platform is gaining traction due to its innovative integration of AI and blockchain, real-world utility, and deflationary tokenomics. Analysts project significant growth potential, comparable to successful blockchain projects like Solana. In summary, Lightchain AI presents a promising solution for enhancing blockchain operations through AI computations, offering a secure, scalable, and privacy-preserving ecosystem for the next generation of decentralized applications.

The State Bank of Pakistan (SBP), established on July 1, 1948, serves as the central bank of Pakistan. This overview highlights its key roles, functions, and evolution: ### Legal Framework The SBP operates under the State Bank of Pakistan Order 1948 and the State Bank of Pakistan Act 1956, with subsequent amendments forming the basis of its operations. ### Primary Functions - Issuance of currency - Conduct of monetary policy - Regulation and supervision of the financial system - Acting as a bankers' bank and lender of last resort - Serving as the banker to the Government ### Secondary Functions - Management of public debt and foreign exchange reserves - Advising the Government on policy matters - Maintaining relationships with international financial institutions ### Developmental Roles - Developing financial frameworks and institutionalizing savings and investment - Providing training through the National Institute of Banking and Finance (NIBAF) - Promoting microfinance, SMEs, and agricultural finance - Encouraging Islamic banking and financial instruments ### Organizational Structure - Central bank (core functions) - SBP-Banking Services Corporation (SBP-BSC) (retail arm) - National Institute of Banking and Finance (NIBAF) (training) - Other subsidiaries: Deposit Protection Corporation and Pakistan Security Printing Corporation ### Governance The Board of Directors, appointed by the Federal Government, oversees SBP's affairs, supported by various subcommittees. ### Evolution and Reforms - Nationalized in 1974 - Implemented financial sector reforms in the 1980s - Introduced technological advancements for modernization - Launched initiatives like SBP Vision 2020 ### Current Initiatives - Enhancing financial inclusion and access to finance - Developing robust payment systems - Strengthening organizational efficiency and effectiveness The State Bank of Pakistan continues to play a crucial role in regulating the country's financial system, implementing monetary policy, and driving economic development.